For Simplicity One Can Think Of The + Class As Having One Extra Base At Some Point Or Other In The Genetic Message And The - Class As Having One Too Few.

For simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the - class as having one too few.

Francis Crick

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Do codons overlap? In other words, as we read along the genetic message do we find a base which is a member of two or more codons? It now seems fairly certain that codons do not overlap.

Francis Crick

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Attempts have been made from a study of the changes produced by mutation to obtain the relative order of the bases within various triplets, but my own view is that these are premature until there is more extensive and more reliable data on the composition of the triplets.

Francis Crick

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A final proof of our ideas can only be obtained by detailed studies on the alterations produced in the amino acid sequence of a protein by mutations of the type discussed here.

Francis Crick

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A comparison between the triplets tentatively deduced by these methods with the changes in amino acid sequence produced by mutation shows a fair measure of agreement.

Francis Crick

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