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It is not accidental that all phenomena of human life are dominated by the search for daily bread - the oldest link connecting all living things, man included, with the surrounding nature.
It is clear to all that the animal organism is a highly complex system consisting of an almost infinite series of parts connected both with one another and, as a total complex, with the surrounding world, with which it is in a state of equilibrium.
It has long been known for sure that the sight of tasty food makes a hungry man's mouth water; also lack of appetite has always been regarded as an undesirable phenomenon, from which one might conclude that appetite is essentially linked with the process of digestion.
It goes without saying that the desire to accomplish the task with more confidence, to avoid wasting time and labour, and to spare our experimental animals as much as possible, made us strictly observe all the precautions taken by surgeons in respect to their patients.
In the case of the stomach, however, the nerves of the glandular cells were always severed when constructing an artificially isolated pouch and this, naturally, affected the normal work of the stomach.
From the described experiment it is clear that the mere act of eating, the food even not reaching the stomach, determines the stimulation of the gastric glands.
Finally, as the digestive canal is a complex system, a series of separate chemical laboratories, I cut the connections between them in order to investigate the course of phenomena in each particular laboratory; thus I resolved the digestive canal into several separate parts.
Edible substances evoke the secretion of thick, concentrated saliva. Why? The answer, obviously, is that this enables the mass of food to pass smoothly through the tube leading from the mouth into the stomach.
Don't become a mere recorder of facts, but try to penetrate the mystery of their origin.
But man has still another powerful resource: natural science with its strictly objective methods.
As was to be expected, the discovery of the nervous apparatus of the salivary glands immediately impelled physiologists to seek a similar apparatus in other glands lying deeper in the digestive canal.
Appetite, craving for food, is a constant and powerful stimulator of the gastric glands.
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